页数:0         字数:0           图表数:0            出版时间：2006年12月

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U.S. DNA Sequencing Technology Markets

Table of Contents

C h a p t e r 1

Executive Summary

Market Overview 1-1

Introduction 1-1

C h a p t e r 2

Total DNA Sequencing Technology Market

Market Overview 2-1

Introduction 2-1

Scope and Segmentation 2-2

Research Methodology 2-4

Base Market Assumptions 2-4

Forecast Methodology 2-4

Restraints in Forecasts 2-5

Market Engineering Measurements 2-5

Market Age 2-7

Current Market Size 2-7

Base Year Market Growth Rate 2-7

Potential Revenues 2-8

Compound Annual Growth Rate 2-8

Price Sensitivity 2-8

Number of Different Products 2-8

Competitors 2-8

Degree of Competition 2-8

Degree of Technical Change 2-9

Market concentration 2-9

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Market Forecast and Competitive Analysis 2-9

Revenue Forecasts 2-9

Competitive Structure 2-14

Market Share Analysis 2-17

Partnerships Mergers and Acquisitions 2-19

454 Life Sciences and Roche Applied Science Reached

Development, Promotion, Sale, and Distribution Agreement 2-19

Applied Biosystems Invested in VisiGen Biotechnologies, Inc. 2-19

Solexa, Inc. and Invitrogen Corporation Reached Supply Agreement 2-20

Applied Biosystems Acquired Agencourt Personal Genomics 2-20

Solexa, Inc. and New England Biolabs Inc. Reached Supply Agreement 2-20

Illumina, Inc. Acquired Solexa, Inc. 2-20

Market Challenges and Strategic Recommendations 2-20

Industry Challenges 2-20

Uncertain Path to $1,000 Genome Complicates Competitive Strategies 2-21

High Instrument Costs Result in Centralized Sequencing 2-22

Complexities Surround Technology Integration 2-23

Unpredictable Time to Market Obscures Opportunities 2-23

Shrinking NIH Budget Slows Market Growth 2-24

Limited Manufacturing, Marketing, and Distribution Capabilities Hinder Success 2-25

Intellectual Property Issues Give Rise to Caution 2-25

Strategic Recommendations 2-26

Focus on Evolving Aims of Genomics Research 2-27

Enable Straightforward Technology Integration 2-28

Develop Strategies with an Appreciation for the Market’s Evolution 2-29

Target Unconventional Industries and Niche Markets to Expand Market Potential 2-30

Co-market instruments and Applications with Complementary Technologies 2-31

Support Academia's Role in Developing Applications and Informatics 2-31

Maintain Broad Value Proposition with Relation to Discovery, Validation, and Commercialization 2-32

C h a p t e r 3

Chain Terminator DNA Sequencing Market

Market Overview 3-1

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Introduction 3-1

Market Engineering Measurements 3-2

Market Age 3-3

Current Market Size 3-4

Base Year Market Growth Rate 3-4

Potential Revenues 3-4

Compound Annual Growth Rate 3-4

Price Sensitivity 3-5

Number of Different Products 3-5

Competitors 3-5

Degree of Competition 3-5

Degree of Technical Change 3-6

Market concentration 3-6

Market Drivers and Restraints 3-6

Market Drivers 3-6

Utilization of Low-to-medium Throughput Technologies Sustains the Majority of Revenue Generation 3-7

Applications Specific to Directed Sequencing Support Market Segment Performance 3-8

Commercialization of Sequencing-based Diagnostic Applications Propels Market Growth 3-9

Utilization of Hybrid Approach to Sequencing Promotes Large-scale Genome Sequencing 3-10

Publicly Funded Large-scale Genome Sequencing Efforts Bolster Revenue Growth from Consumables Sales 3-11

Falling Costs Associated with Technological Advancements and Workflow Optimization Boost Applications 3-12

Market Restraints 3-13

Inefficiency and Costliness of Technology Prevent Utilization 3-14

Saturated Market for High-throughput Technologies Limits Growth of Install Base 3-15

Market Disruption Made by Next Generation DNA Sequencing Technologies Hinders Adoption Rates 3-16

Complexity of Upstream Sample Preparation Deters Adoption and Decentralization of Install Base 3-17

Competition by Alternative Genomics Technologies Constrains Market Share 3-18

Economic Advantage of Outsourcing Curbs Decentralization of Instrumentation 3-19

Reagent Dilution Slows Revenue Generation from Consumables Sales 3-20

Technology and Market Trends 3-21

Technology Trends 3-21

Two-fold Innovation: Instrumentation Improvement and Application Development 3-21

Instrumentation Improvement 3-21

Application Development 3-22

Next Generation Chain Terminator DNA Sequencing Technologies 3-23

Microchip Biotechnologies, Inc. 3-24

Market forecasts, trends, and competitive analysis for Microchip Biotechnologies, Inc., are

included in the Next Generation DNA Sequencing segment chapter. 3-25

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Network Biosystems 3-25

Market forecasts, trends, and competitive analysis for Network Biosystems are included in

the Next Generation DNA Sequencing segment chapter. 3-25

Market Trends 3-25

Market Transition from Discovery to Validation 3-28

The Cancer Genome Atlas 3-28

Medical Sequencing Program 3-29

Forensics 3-29

Market Forecasts and Competitive Analysis 3-31

Revenue Forecasts 3-31

Overview 3-34

Discovery and Validation 3-35

Clinical Research 3-36

Commercialized Applications 3-36

Conclusion 3-37

Competitive Structure 3-37

Tier I Market Participant 3-39

Applied Biosystems 3-39

Tier II Market Participants 3-41

GE Healthcare 3-41

Beckman Coulter, Inc. 3-42

LI-COR Biosciences, Inc. 3-43

Tier III Market Participants 3-44

Market Share Analysis 3-45

C h a p t e r 4

Next Generation DNA Sequencing Market

Market Overview 4-1

Introduction 4-1

Market Engineering Measurements 4-2

Market Age 4-3

Current Market Size 4-4

Base Year Market Growth Rate 4-4

Potential Revenues 4-4

Compound Annual Growth Rate 4-4

Price Sensitivity 4-4

Number of Different Products 4-5

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Competitors 4-5

Degree of Competition 4-5

Degree of Technical Change 4-5

Market concentration 4-5

Market Drivers and Restraints 4-6

Market Drivers 4-6

Efficiency and Cost-Effectiveness of Technologies Drive Growth 4-11

Intended, Anticipated, and Unforeseen Applications Propel Growth 4-12

Share of Alternative Technologies’ Existing Market Revenues Boosts Near-term Growth 4-13

The Cancer Genome Atlas Propels Utilization 4-14

The Medical Sequencing Program Propels Utilization 4-16

Demand for Rapid and Sensitive Infectious Disease Testing Technology Accelerates Adoption 4-17

Funding for Technology Development Promotes Commercialization 4-18

Government Support of Instrument Procurement Supports Adoption 4-19

Innovation Driven by $1,000 Genome Endeavor Accelerates Market Evolution 4-20

Market Restraints 4-21

Technological Limitations Prevents Immediate Adoption 4-21

Insufficient Proof-of-principle Discourages End Users’ Investment 4-22

Hesitation amongst Potential End-users Curbs Adoptions 4-23

Data Overload Limits Applications 4-24

Instrument Costs Slow Adoption Rates 4-25

Competition by Alternative Genomics Technologies Constrains Growth 4-26

Disruptive Technologies Limit Growth 4-27

Technology and Market Trends 4-28

Technology Trends 4-28

Review of Next Generation DNA Sequencing Technologies 4-28

454 Life Sciences (Roche Applied Science) 4-30

Applied Biosystems (Agencourt Personal Genomics) 4-30

GE Global Research 4-30

Genovoxx GmbH 4-30

Helicos BioSciences Corporation 4-31

Intelligent Bio-Systems, Inc. 4-31

LI-COR Biosciences 4-31

Microchip Biotechnologies, Inc. 4-31

Mobious Genomics 4-31

Network Biosystems 4-32

Pacific Biosciences (Nanofluidics) 4-32

Solexa (Illumina Inc.) 4-32

VisiGen Biotechnologies, Inc. 4-32

Combination of Solid-state Nanopores with Surface Enhanced Raman Spectroscopy for Ultra-high Throughput Realtime

Single Molecule DNA Sequencing 4-33

Market Trends 4-34

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Potential Applications of Technologies 4-34

Large-scale Whole Human Genome Sequencing and Resequencing 4-34

Comparative Genome Sequence Analysis 4-35

Infectious Disease Testing 4-35

Sequencing Unique or Specific Genomes for Research in Bioarchaeology, Anthropology,

Evolution, and Human Migration 4-35

Sequencing Degraded Samples 4-36

Whole Genome Expression Profiling 4-36

Complement Hybridization Arrays 4-36

Small RNA Discovery and Quantification 4-37

Functional Genomics Analyses 4-37

Eco-Perspective Sequencing 4-38

Next Generation DNA Sequencing as a Service Offering 4-38

Market Forecasts and Competitive Analysis 4-39

Revenue Forecasts 4-39

Competitive Structure 4-42

Tier I Market Participant 4-46

454 Life Sciences (Roche Applied Science) 4-46

Projected Market Entrants 4-48

Applied Biosystems (Agencourt Personal Genomics) 4-48

Helicos BioSciences Corporation 4-48

Microchip Biotechnologies, Inc. 4-49

Network Biosystems 4-49

Solexa (Illumina Inc.) 4-49

Prospective Market Entrants 4-50

Market Share Analysis 4-51

C h a p t e r 5

Decision Support Database

Decision Support Database 5-1

Number of Biotechnology Companies 5-1

Private Investment in Biotechnology 5-3

Government Biotechnology R&D Investment 5-5

Total Healthcare Expenditures 5-8

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List of Figures

Ch a p t e r 2

Total DNA Sequencing Technology Market

2-1 Total DNA Sequencing Technology Market:

Revenue Forecasts (U.S.), 2002-2012 2-10

2-2 Total DNA Sequencing Technology Market:

Revenue Forecasts by Segment (U.S.), 2002-2012 2-11

2-3 Total DNA Sequencing Technology Market:

Percent of Revenues by Segment (U.S.), 2002-2012 2-12

2-4 Total DNA Sequencing Technology Market:

Competitive Structure (U.S.), 2005 2-14

2-5 Total DNA Sequencing Technology Market:

Company Market Share by Revenues (U.S.), 2005 2-18

2-6 Total DNA Sequencing Technology Market:

Impact of Top Industry Challenges (U.S.), 2006-2012 2-21

2-7 Total DNA Sequencing Technology Market:

Challenges and Corresponding Strategic Recommendations (U.S.), 2006-2012 2-26

Ch a p t e r 3

Chain Terminator DNA Sequencing Market

3-1 Chain Terminator DNA Sequencing Market:

Market Drivers Ranked in Order of Impact (U.S.), 2006-2012 3-6

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3-2 Chain Terminator DNA Sequencing Market:

Market Restraints Ranked in Order of Impact (U.S.), 2006-2012 3-13

3-3 Chain Terminator DNA Sequencing Market:

Public Funding for Large-scale Sequencing Projects by Aim (U.S.), 2003-2012 3-26

3-4 Chain Terminator DNA Sequencing Market:

Percent of Public Funding for Large-scale Sequencing Projects by Aim (U.S.), 2003-2012 3-27

3-5 Chain Terminator DNA Sequencing Market:

Revenue Forecasts (U.S.), 2002-2012 3-31

3-6 Chain Terminator DNA Sequencing Market:

Revenue Forecasts by Application (U.S.), 2002-2012 3-32

3-7 Chain Terminator DNA Sequencing Market:

Percent of Revenues by Application (U.S.), 2002-2012 3-33

3-8 Chain Terminator DNA Sequencing Market:

Competitive Structure (U.S.), 2005 3-37

3-9 Chain Terminator DNA Sequencing Market:

Company Market Share by Revenues (U.S.), 2005 3-46

Ch a p t e r 4

Next Generation DNA Sequencing Market

4-1 Next Generation DNA Sequencing Market:

Market Drivers Ranked in Order of Impact (U.S.), 2006-2012 4-6

4-2 Next Generation DNA Sequencing Market:

Revenue Forecasts for Related Genetic Analysis Technologies (U.S.), 2005 and 2010 4-6

4-3 Next Generation DNA Sequencing Market:

Public Funding for Technology Development by Initiative (U.S.), 2004-2012 4-10

4-4 Next Generation DNA Sequencing Market:

Market Restraints Ranked in Order of Impact (U.S.), 2006-2012 4-21

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4-5 Next Generation DNA Sequencing Market:

Revenue Forecasts (U.S.), 2002-2012 4-39

4-6 Next Generation DNA Sequencing Market:

Competitive Structure (U.S.), 2005 4-43

4-7 Next Generation DNA Sequencing Market:

Company Market Share by Revenues (U.S.), 2005 4-51

Ch a p t e r 5

Decision Support Database

5-1 Decision Support Database:

Biotech Companies in (World), 2002-2012 5-1

5-2 Decision Support Database:

Venture Capital investment in biotech R & D Mn USD In (World), 2002-2012 5-3

5-3 Decision Support Database:

Government R & D Expenditure in Biotechnology Mn USD In (World), 2002-2012 5-6

5-4 Decision Support Database:

Total Healthcare Expenditure (Bn USD) 5-8

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List of Charts

Ch a p t e r 2

Total DNA Sequencing Technology Market

2.1 Total DNA Sequencing Technology Market:

Market Engineering Measurements (U.S.), 2005 2-6

2.2 Total DNA Sequencing Technology Market:

Revenue Forecasts (U.S.), 2002-2012c 2-10

2.3 Total DNA Sequencing Technology Market:

Revenue Forecasts by Segment (U.S.), 2002-2012 2-12

2.4 Total DNA Sequencing Technology Market:

Percent of Revenues by Segment (U.S.), 2002-2012 2-13

2.5 Total DNA Sequencing Technology Market:

Company Market Share by Revenues (U.S.), 2005 2-18

Ch a p t e r 3

Chain Terminator DNA Sequencing Market

3.1 Chain Terminator DNA Sequencing Market:

Market Engineering Measurements (U.S.), 2005 3-3

3.2 Chain Terminator DNA Sequencing Market:

Market Restraints due to Lack of Efficiency and Cost-effectiveness (U.S.), 2006-2012 3-14

3.3 Chain Terminator DNA Sequencing Market:

Public Funding for Large-scale Sequencing Projects by Aim (U.S.), 2003-2 3-26

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3.4 Chain Terminator DNA Sequencing Market:

Percent of Public Funding for Large-scale Sequencing Projects by Aim (U.S.), 2003-2012 3-27

3.5 Chain Terminator DNA Sequencing Market:

Revenue Forecasts (U.S.), 2002-2012 3-32

3.6 Chain Terminator DNA Sequencing Market:

Revenue Forecasts by Application (U.S.), 2002-2012 3-33

3.7 Chain Terminator DNA Sequencing Market:

Percent of Revenues by Application (U.S.), 2002-2012 3-34

3.8 Chain Terminator DNA Sequencing Market:

Company Market Share by Revenues (U.S.), 2005 3-46

Ch a p t e r 4

Next Generation DNA Sequencing Market

4.1 Next Generation DNA Sequencing Market:

Market Engineering Measurements (U.S.), 2005 4-3

4.2 Next Generation DNA Sequencing Market:

Revenue Forecasts for Related Genetic Analysis Technologies (U.S.), 2005 and 2010 4-7

4.3 Next Generation DNA Sequencing Market:

Technology Development Grants (U.S.), 2004-2006 4-8

4.4 Next Generation DNA Sequencing Market:

Public Funding for Technology Development by Initiative (U.S.), 2004-2012 4-10

4.5 Next Generation DNA Sequencing Market:

Technology Review (U.S.), 2005 4-28

4.6 Next Generation DNA Sequencing Market:

Revenue Forecasts (U.S.), 2002-2012 4-40

4.7 Next Generation DNA Sequencing Market:

Market Entrances (U.S.), 2005-2009 4-44